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    Multicentre, double-blind study of 94 patients suffering from either external hemorrhoidal thrombosis requiring medical treatment or internal congestive hemorrhoidal crisis who were randomized to diosmin 600mg (3 tablets TID for 4 days and 2 tablets/day for 3 days) or placebo.
  3. Debien P, Denis J. Traitement des signes fonctionnels de la crise hémorroïdaire aiguë (Treatment of functional symptoms of acute hemorrhoidal attack). Actualités Therapéutiques 1996;25(5):259-64. Multicentre, double-blind study of 127 patients suffering from hemorrhoidal crisis with pain evolving for at least 48 hrs, who were randomized to diosmin (DH) 600 mg (3 tablets/day for 7 days) or Ginkgo biloba extract-heptamitol-troxerutin (GHT) (4 tablets/day for 7 days).
  4. Metrika. Hemorrhoid Market U&A and NPOT Study: Report of Findings. November, 2013.
    Online market research survey conducted between October 7 and 17, 2013 among 1000 hemorrhoid sufferers across Canada who had bought an OTC hemorrhoid treatment in the past 6 months.
  5. Natural Medicines Comprehensive Database - Online. Diosmin Monograph. Accessed September 26, 2013.
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    Hemorrhoids | NIDDK (
  7. Mayo Clinic. Hemorrhoids. Available at:
    Hemorrhoids - Symptoms and causes - Mayo Clinic
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    cpg_management_of_hemorrhoids.pdf (
  9. Everything You Should Know About Thrombosed Hemorrhoids